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Pipeline

Celyad Oncology is building a diversified pipeline of next-generation allogeneic and autologous CAR T candidates
Allogeneic Target Indication Preclinical Phase 1 Phase 2 Next milestones

CYAD-211

BCMA r/r MM
Additional clinical data expected H2:2022

CYAD-211 is a short hairpin RNA (shRNA)-based allogeneic CAR T candidate for the treatment of relapsed or refractory multiple myeloma (r/r MM). CYAD-211 is engineered to co-express a B-cell maturation antigen (BCMA) chimeric antigen receptor and a single shRNA hairpin which interferes with the expression of the CD3ζ component of the TCR complex.

CYAD-211 is currently being evaluated, following Cyflu chemotherapy, in the Phase 1 IMMUNICY-1 trial for the treatment of relapsed/refractory multiple myeloma.

Trial
IMMUNICY-1
Stage
Phase 1
Design
Preconditioning with CyFlu
About the Trial
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CYAD-101

NKG2DL mCRC
Update on CYAD-101-002 trial

CYAD-101 is an investigational, non-gene edited allogeneic (from healthy donor derived) CAR T candidate engineered to co-express the chimeric antigen receptor based on NKG2D, a receptor expressed on natural killer (NK) cells that binds to eight stress-induced ligands (NKG2DL) expressed by a broad range of tumor cells and the novel inhibitory peptide TIM (TCR Inhibitory Molecule). The expression of TIM reduces signaling of the TCR complex by interfering with the CD3ζ component of the TCR complex.

CYAD-101 is currently being evaluated in the Phase 1b KEYNOTE-B79 trial with Merck’s anti-PD­1 therapy, KEYTRUDA®️ (pembrolizumab), in refractory mCRC patients with microsatellite stable / mismatch-repair proficient disease.

Trial
KEYNOTE-B79
Stage
Phase 1
Design
Preconditioning with FOLFOX
About the Trial
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Discovery Programs

Autologous Target Indication Preclinical Phase 1 Phase 2 Next milestones

CYAD-02

NKG2DL r/r AML/MDS
Potential partnership opportunity

CYAD-02 is an investigational CAR T therapy that engineers an all-in-one vector approach in patient’s T cells to express both (i) the NKG2D chimeric antigen receptor, a receptor expressed on natural killer (NK) cells that binds to eight stress-induced ligands (NKG2DL) expressed on tumor cells, and (ii) short hairpin RNA (shRNA) technology to knockdown the expression of NKG2D ligands MICA and MICB on the CAR T cells. In preclinical models, shRNA-mediated knockdown of MICA and MICB expression on NKG2D CAR T cells has shown enhanced in vitro expansion, as well as enhanced in vivo engraftment and persistence, of the CAR T cells, as compared to first-generation NKG2D-based CAR T cells.

In December 2021, the Company presented clinical results from the dose-escalation CYCLE-1 Phase 1 trial evaluating CYAD-02 for the treatment of relapsed or refractory (r/r) acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS).

Trial
CYCLE-1
Stage
Phase 1
Design
Preconditioning with CyFlu
About the Trial
LEARN MORE

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