Pipeline
Allogeneic | Target | Indication | Preclinical | Phase 1 | Phase 2 | Next milestones |
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CYAD-211 |
BCMA | r/r MM |
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Additional clinical data expected H2:2022 | ||
CYAD-211 is a short hairpin RNA (shRNA)-based allogeneic CAR T candidate for the treatment of relapsed or refractory multiple myeloma (r/r MM). CYAD-211 is engineered to co-express a B-cell maturation antigen (BCMA) chimeric antigen receptor and a single shRNA hairpin which interferes with the expression of the CD3ζ component of the TCR complex. CYAD-211 is currently being evaluated, following Cyflu chemotherapy, in the Phase 1 IMMUNICY-1 trial for the treatment of relapsed/refractory multiple myeloma.
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Discovery Programs |
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Autologous | Target | Indication | Preclinical | Phase 1 | Phase 2 | Next milestones |
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CYAD-02 |
NKG2DL | r/r AML/MDS |
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Potential partnership opportunity | ||
CYAD-02 is an investigational CAR T therapy that engineers an all-in-one vector approach in patient’s T cells to express both (i) the NKG2D chimeric antigen receptor, a receptor expressed on natural killer (NK) cells that binds to eight stress-induced ligands (NKG2DL) expressed on tumor cells, and (ii) short hairpin RNA (shRNA) technology to knockdown the expression of NKG2D ligands MICA and MICB on the CAR T cells. In preclinical models, shRNA-mediated knockdown of MICA and MICB expression on NKG2D CAR T cells has shown enhanced in vitro expansion, as well as enhanced in vivo engraftment and persistence, of the CAR T cells, as compared to first-generation NKG2D-based CAR T cells. In December 2021, the Company presented clinical results from the dose-escalation CYCLE-1 Phase 1 trial evaluating CYAD-02 for the treatment of relapsed or refractory (r/r) acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS).
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