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Uncategorized

Publication of a transparency notification received from Tolefi SA (Article 14§1 of the Law of 2 May 2007)

July 28, 2026 Hannes Iserentant

Mont-Saint-Guibert, Belgium; July 28, 2026, 08:30 pm CET; regulated information – Celyad Oncology (Euronext: CYAD) (the “Company” or “Celyad Oncology”), today announced, in accordance with Article 14 of the Belgian Law of 2 May 2007 regarding the publication of major shareholdings in issuers whose securities are admitted to trading on a regulated market (the “Transparency Law”), that it received a transparency notification dated July 24, 2026, from Tolefi SA and related persons indicating that they have jointly crossed passively below the 10% threshold, holding 6,568,978 shares, or 8.77% of the voting rights of the Company as of July 16, 2026.

Content of the Notification:

  • Reason of the notification:
  • Passive crossing of threshold
  • Notification by:
  • Persons acting in concert
  • Persons subject to the notification requirement:
  • Tolefi SA, Chaussée de Waterloo 1589D, 1180 Brussels
  • Serge Goblet
  • Isabelle Thoumyre
  • Jérôme Goblet
  • Jean-Daniel Goblet
  • Date on which the threshold is crossed:
  • July 16, 2026
  • Threshold that is crossed (in %):
  • 10
  • Denominator:
  • 74,883,166
  • Notified details:
Voting RightsPrevious notificationAfter the transaction
 # of voting rights# of voting rights% of voting rights
Holders of voting rights Linked to the securitiesNot linked to the securitiesLinked to the securitiesNot linked to the securities
Serge GOBLET56,18056,18000.08%0.00%
Isabelle THOUMYRE7,3007,30000.01%0.00%
Tolefi SA6,504,8646,504,86408.69%0.00%
Subtotal6,568,3446,568,34408.77%0.00%
Jérôme GOBLET25025000.00%0.00%
Jean-Daniel GOBLET38438400.00%0.00%
 TOTAL6,568,97808.77%0.00%
  •  
Equivalent financial instrumentsAfter the transaction 
Holders of equivalent financial instrumentsType of financial instrumentExpiration dateExercise period or date# of voting rights that may be acquired if the instrument is exercised% of voting rightssettlement
       
 TOTAL  00.00% 
Total (A&B)# of voting rights% of voting rights
 6,568,9788.77%
  • Full chain of controlled undertakings through which the holding is effectively held:
  • Tolefi SA is controlled by Mr. Serge Goblet and Mrs. Isabelle Thoumyre, according to articles 1:14-1.18 of the Code of companies and associations
  •  
  •  

Miscellaneous:

  • The Press Release may be consulted on the website of Celyad Oncology:
  • https://celyad.com/newsroom
  • The notification can be consulted on the website of Celyad Oncology:
  • https://celyad.com/investors/regulated-information/
  • Contact person(s):
  • Any transparency notification must be sent to our Company by email to the attention of Hannes Iserentant, General Manager: investors@celyad.com
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Filed Under: Press Releases, regulated information, Uncategorized

Information on the Total Number of Voting Rights and Shares (Article 15 of the Law of 2 May 2007)

July 22, 2026 Hannes Iserentant

Mont-Saint-Guibert, Belgium; July 22, 2026, 08:30 pm CET; regulated information – Celyad Oncology (Euronext: CYAD) (the “Company” or “Celyad Oncology”), today announces the below information following the issuance, on July 16, 2026, of 2,500,000 new shares of Celyad Oncology to an affiliate of Fortress Investment Group. As a result, the Company’s share capital has been increased to 10,437,000.00 EUR and is represented by 47,261,905 shares.

This information is published in accordance with Article 15 of the Belgian Law of 2 May 2007 on the disclosure of major participations in issuers whose shares are admitted to trading on a regulated market and regarding miscellaneous provisions.

Figures – Modified on July 16, 2026, following the capital increase:

Total amount of share capital (EUR)10,437,000.00
Total Number of shares with single voting rights19,640,644
Total Number of shares with double voting rights27,621,261
Total Number of Shares47,261,905
Total of voting rights74,883,166
Total number of attributed warrants3,487,923
Total number of shares with voting rights that could be created following the exercise of the attributed warrants3,487,923
Total number of diluted shares (Outstanding shares + Warrants)50,749,828
Total number of diluted shares with voting rights78,371,089

Contact person for regulated information (financial, transparency)

By law, any transparency declaration must be sent to our Company by email to the attention of Hannes Iserentant, general manager: investors@celyad.com.

Further questions about the content of this release can be sent to investors@celyad.com.

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Filed Under: Press Releases, regulated information, Uncategorized

Celyad Oncology Announces €500,000 Private Placement

July 14, 2026 Hannes Iserentant

Mont-Saint-Guibert, Belgium; 14 July 2026, 7am CET – Regulated information – inside information

Celyad Oncology SA (Euronext: CYAD) (the “Company” or “Celyad Oncology”), today announced that it has entered into a subscription agreement for a private placement financing (the “Transaction”) with an affiliate of Fortress Investment Group LLC (“Fortress Investment Group”).

Under the terms of the subscription agreement, CFIP CLYD (UK) Limited (“Fortress”) will subscribe to a capital increase for an aggregate amount of €500,000 in exchange for 2,500,000 newly issued ordinary shares of Celyad Oncology. The shares will be issued at a subscription price of €0.20 per share, which represents a 15% discount to the volume-weighted average price (VWAP) of Celyad Oncology’s shares on Euronext Brussels over the ten (10) trading days preceding the date of the advice of the committee of independent directors. The private placement is expected to close on or around 15 July 2026, subject to the satisfaction of customary closing conditions.

The private placement is being conducted within the limits of the Company’s authorized capital as approved by the Extraordinary Shareholders’ Meeting of 14 November 2023, with cancellation of the preferential subscription rights of the existing shareholders in favour of Fortress. Following and subject to the issue of the shares to Fortress, Fortress is expected to hold approximately 60.52% of the Company’s outstanding shares and approximately 68.75% of the voting rights.

The net proceeds of the private placement will be used for working capital and general corporate purposes.  The Company believes that following the consummation of the private placement, its cash runway will be extended from Q3 2026 to mid Q2 2027, providing additional time for the Company to identify, pursue, and implement opportunities to strengthen its balance sheet. The subscription agreement contains customary representations, warranties and covenants of the Company and Fortress.

As Fortress qualifies as a related party of the Company within the meaning of article 7:97 of the Belgian Code of Companies and Associations (the “BCCA”) on account of its shareholding in the Company and its representation on the board of directors, the board of directors applied Article 7:97 of the BCCA, which requires, among other things, the intervention of a committee of independent directors to give an opinion to the board of directors. The conclusions of the committee’s opinion is as follows: “The Committee has assessed the envisaged Transaction in light of the criteria included in article 7:97 of the BCCA and concluded, in view of the Company’s financial situation and cash flow requirements, after considering and examining alternative funding options and taking into account the interest of all stakeholders, that the expected advantages of the Transaction outweigh the expected disadvantages thereof, which leads to the conclusion that the Transaction is to the advantage and in the interest of the Company. The Transaction is in line with the Company’s strategic policy and is not manifestly unreasonable and the Committee affirms its positive advice in relation to the Transaction”. In accordance with article 7:97, §2 of the BCCA, the directors nominated by Fortress did not participate in the deliberations or votes of the board of directors on the Transaction. In light of the Company’s limited cash runway, the board of directors believes that the envisaged capital increase is in the best interests of the Company and its stakeholders because, if completed, the capital increase will give additional time for the Company to identify, pursue, and implement opportunities to strengthen its balance sheet. In accordance with article 7:97 of the BCCA, the Company’s auditor has issued a report on the accounting and financial information contained in the committee’s opinion and the board minutes approving the related party transaction. The auditor’s conclusion in this respect is as follows: “Based on our assessment, nothing has come to our attention that causes us to believe that the accounting and financial information included in the advice of the committee of independent directors dated July 10, 2026 and in the minutes of the Board of Directors dated July 13, 2026, justifying the proposed transaction, contain material inconsistencies with regard to the information available to us within the scope of our mission.”.

About Celyad Oncology

Celyad Oncology is a biotechnology company focused primarily on unlocking the potential of its intellectual property particularly related to CAR-T technology platforms.  The Company is headquartered in Mont-Saint-Guibert, Belgium.  For more information, visit www.celyad.com.

About Fortress Investment Group

Fortress Investment Group is a leading, highly diversified global investment manager. Founded in 1998, Fortress Investment Group manages $54 billion of assets under management as of March 31, 2026, on behalf of approximately 2,000 institutional clients and private investors worldwide across a range of credit and real estate, private equity and permanent capital investment strategies. AUM refers to assets Fortress Investment Group manages, including capital that Fortress Investment Group has the right to call from investors, or investors are otherwise required to contribute, pursuant to their capital commitments to various funds or managed accounts. For more information, please visit www.fortress.com.

Forward-Looking Statements

This press release may contain forward-looking statements, including, without limitation, statements regarding beliefs about and expectations for the Company’s cash runway, statements regarding the Company’s future fundraising plans, and statements regarding the continuation of the Company’s existence.  The words “will,” “potential,” “continue,” “target,” “project,” “should,” “believe” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Any forward-looking statements in this press release are based on management’s current expectations and beliefs and are subject to a number of known and unknown risks, uncertainties and important factors which might cause actual events, results, financial condition, performance or achievements of Celyad Oncology to differ materially from those expressed or implied by such forward-looking statements. Such risks and uncertainties include, without limitation, risks related to the material uncertainty about the Company’s ability to continue as a going concern; the Company’s ability to realize the expected benefits of its strategic focus; the Company’s ability to develop its intellectual property (“IP”) assets and enter into partnerships with outside parties; the Company’s ability to enforce its patents and other IP rights; the possibility that the Company may infringe on the patents or IP rights of others and be required to defend against patent or other IP rights suits; the possibility that the Company may not successfully defend itself against claims of patent infringement or other IP rights suits, which could result in substantial claims for damages against the Company; the possibility that the Company may become involved in lawsuits to protect or enforce its patents, which could be expensive, time-consuming, and unsuccessful; the Company’s ability to protect its IP rights throughout the world; the potential for patents held by the Company to be found invalid or unenforceable; and other risks identified in the latest Annual Report of Celyad Oncology. These forward-looking statements speak only as of the date of publication of this press release and Celyad Oncology’s actual results may differ materially from those expressed or implied by these forward-looking statements. Celyad Oncology expressly disclaims any obligation to update any such forward-looking statements in this press release to reflect any change in its expectations with regard thereto or any change in events, conditions or circumstances on which any such statement is based, unless required by law or regulation.

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Filed Under: inside information, Press Releases, regulated information, Uncategorized

Celyad Oncology published a review in ‘Frontiers in Immunology’ – Engineering strategies to safely drive CAR T-cells into the future

July 1, 2024 Caroline Lonez

Abstract: Chimeric antigen receptor (CAR) T-cell therapy has proven a breakthrough in cancer treatment in the last decade, giving unprecedented results against hematological malignancies. All approved CAR T-cell products, as well as many being assessed in clinical trials, are generated using viral vectors to deploy the exogenous genetic material into T-cells. Viral vectors have a long-standing clinical history in gene delivery, and thus underwent iterations of optimization to improve their efficiency and safety. Nonetheless, their capacity to integrate semi-randomly into the host genome makes them potentially oncogenic via insertional mutagenesis and dysregulation of key cellular genes. Secondary cancers following CAR T-cell administration appear to be a rare adverse event. However several cases documented in the last few years put the spotlight on this issue, which might have been underestimated so far, given the relatively recent deployment of CAR T-cell therapies. Furthermore, the initial successes obtained in hematological malignancies have not yet been replicated in solid tumors. It is now clear that further enhancements are needed to allow CAR T-cells to increase long-term persistence, overcome exhaustion and cope with the immunosuppressive tumor microenvironment. To this aim, a variety of genomic engineering strategies are under evaluation, most relying on CRISPR/Cas9 or other gene editing technologies. These approaches are liable to introduce unintended, irreversible genomic alterations in the product cells. In the first part of this review, we will discuss the viral and non-viral approaches used for the generation of CAR T-cells, whereas in the second part we will focus on gene editing and non-gene editing T-cell engineering, with particular regard to advantages, limitations, and safety. Finally, we will critically analyze the different gene deployment and genomic engineering combinations, delineating strategies with a superior safety profile for the production of next-generation CAR T-cell.

Link to publication

Schematic illustration of different gene delivery methods. Methodologies are divided into in vivo, ex vivo viral and ex vivo non-viral methodologies. Lentiviruses, retroviruses and transposons all are incorporated into the genome, and lead to stable CAR expression (upper half). In contrast, AAV LNP/Nanocarriers and mRNA all lead to transient CAR expression (lower half).

Filed Under: Uncategorized Tagged With: publication

Celyad Oncology published a review in ‘Cells’ – Allogeneic CAR-T Therapy Technologies: Has the Promise Been Met?

January 16, 2024 Caroline Lonez

Abstract: This last decade, chimeric antigen receptor (CAR) T-cell therapy has become a real treatment option for patients with B-cell malignancies, while multiple efforts are being made to extend this therapy to other malignancies and broader patient populations. However, several limitations remain, including those associated with the time-consuming and highly personalized manufacturing of autologous CAR-Ts. Technologies to establish “off-the-shelf” allogeneic CAR-Ts with low alloreactivity are currently being developed, with a strong focus on gene-editing technologies. Although these technologies have many advantages, they have also strong limitations, including double-strand breaks in the DNA with multiple associated safety risks as well as the lack of modulation. As an alternative, non-gene-editing technologies provide an interesting approach to support the development of allogeneic CAR-Ts in the future, with possibilities of fine-tuning gene expression and easy development. Here, we will review the different ways allogeneic CAR-Ts can be manufactured and discuss which technologies are currently used. The biggest hurdles for successful therapy of allogeneic CAR-Ts will be summarized, and finally, an overview of the current clinical evidence for allogeneic CAR-Ts in comparison to its autologous counterpart will be given.

Link to publication

Filed Under: Uncategorized Tagged With: publication

Celyad Oncology published in Molecular Therapy – Nucleic Acids a manuscript detailing our proprietary microRNA (miRNA)-based multiplex shRNA platform

October 4, 2023 Caroline Lonez

Genome engineering technologies are powerful tools in cell-based immunotherapy to optimize or fine-tune cell functionalities. However, their use for multiple gene edits poses relevant biological and technical challenges. Short hairpin RNA (shRNA)-based cell engineering bypasses these criticalities and represents a valid alternative to CRISPR-based gene editing. Here, we describe a microRNA (miRNA)-based multiplex shRNA platform obtained by combining highly efficient miRNA scaffolds into a chimeric cluster, to deliver up to four shRNA-like sequences. Thanks to its limited size, our cassette could be deployed in a one-step process along with all the CAR components, streamlining the generation of engineered CAR T cells. The plug-and-play design of the shRNA platform allowed us to swap each shRNA-derived guide sequence without affecting the system performance. Appropriately choosing the target sequences, we were able to either achieve a functional KO, or fine-tune the expression levels of the target genes, all without the need for gene editing. Through our strategy we achieved easy, safe, efficient, and tunable modulation of multiple target genes simultaneously. This approach allows for the effective introduction of multiple functionally relevant tweaks in the transcriptome of the engineered cells, which may lead to increased performance in challenging environments, e.g., solid tumors.

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Filed Under: Uncategorized Tagged With: publication

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